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Hassan, S., Goda, Y. (2005). Effect of Radiotherapy and Chemotherapy on Normal Jejunal Mucosa of Swiss Mice: Histological, Cytological, and Histochemical Studies. Journal of High Institute of Public Health, 35(1), 19-34. doi: 10.21608/jhiph.2005.179269
Safia M. Hassan; Yousri S. Goda. "Effect of Radiotherapy and Chemotherapy on Normal Jejunal Mucosa of Swiss Mice: Histological, Cytological, and Histochemical Studies". Journal of High Institute of Public Health, 35, 1, 2005, 19-34. doi: 10.21608/jhiph.2005.179269
Hassan, S., Goda, Y. (2005). 'Effect of Radiotherapy and Chemotherapy on Normal Jejunal Mucosa of Swiss Mice: Histological, Cytological, and Histochemical Studies', Journal of High Institute of Public Health, 35(1), pp. 19-34. doi: 10.21608/jhiph.2005.179269
Hassan, S., Goda, Y. Effect of Radiotherapy and Chemotherapy on Normal Jejunal Mucosa of Swiss Mice: Histological, Cytological, and Histochemical Studies. Journal of High Institute of Public Health, 2005; 35(1): 19-34. doi: 10.21608/jhiph.2005.179269

Effect of Radiotherapy and Chemotherapy on Normal Jejunal Mucosa of Swiss Mice: Histological, Cytological, and Histochemical Studies

Article 2, Volume 35, Issue 1, January 2005, Page 19-34  XML
Document Type: Original Article
DOI: 10.21608/jhiph.2005.179269
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Authors
Safia M. Hassan1; Yousri S. Goda2
1Department of Histochemistry and Cell Biology, Medical Research Institute, Egypt
2Radiology Department, Faculty of Medicine, Alexandria University, Egypt
Abstract
Radiation and Chemotherapy play a major role in the management of patients with malignant tumours, they have marked toxicity against tumour cells in addition to other undesirable side effects on normal organs. This led the researchers to carry out histological, cytological, and histochemical studies as regards the effect of radiation and chemotherapy on the jejunal mucosa of normal mice.
Seventy-two male Swiss mice were used in this study. Golgi apparatus, acid phosphatase [ACP], and succinic dehydrogenase [SDH] enzymes were studied in normal jejunum as well as after exposure to radiotherapy and chemotherapy. The results revealed that prominent changes were observed in cisplatin-treated group, while more effects were shown in animals receiving combined radio and chemotherapy.  
Keywords
Radiotherapy; Chemotherapy; Normal Jejunal Mucosa; Swiss Mice
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