Baeshin, N., Ahmed, E., Abo Yousef, A., Alam, S. (2003). Mutagenicity Studies of Cadmium Chloride in Mice. Journal of High Institute of Public Health, 33(2), 359-372. doi: 10.21608/jhiph.2003.196787
N A. Baeshin; E S. Ahmed; A Abo Yousef; S J. Alam. "Mutagenicity Studies of Cadmium Chloride in Mice". Journal of High Institute of Public Health, 33, 2, 2003, 359-372. doi: 10.21608/jhiph.2003.196787
Baeshin, N., Ahmed, E., Abo Yousef, A., Alam, S. (2003). 'Mutagenicity Studies of Cadmium Chloride in Mice', Journal of High Institute of Public Health, 33(2), pp. 359-372. doi: 10.21608/jhiph.2003.196787
Baeshin, N., Ahmed, E., Abo Yousef, A., Alam, S. Mutagenicity Studies of Cadmium Chloride in Mice. Journal of High Institute of Public Health, 2003; 33(2): 359-372. doi: 10.21608/jhiph.2003.196787
1Department of Biology, Faculty of Sciences, King Abdulaziz University, Saudi Arabia
2Department of Biology, National Research Center, Cairo, Egypt
3Department of Genetics, Faculty of Agriculture, Alexandria University, Egypt
Abstract
Cadmium chloride [CdCl2] was tested for its mutagenicity in Swiss albino mice by the dominant lethal mutantion test and the micronuclei test singly or in combination either with nitrosoguanidine [N.T.G.] or ascorbic acid. The results obtained showed that cadmium chloride was a weak mutagen when compared with N.T.G. as a positive control. However, cadmium chloride [CdCl2] and N.T.G. in combination showed significant increase in the dominant lethal mutations when compared with the effect of either [CdCl2] or N.T.G. individually. A statistically significant increase of the frequency of micronucleated erythrocytes was also noticed when CdCl, was combined with either N.T.G. or ascorbic acid as compared with CdCl2 individually.
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