El-Gendy, K., Aly, N. (2011). Alteration of Hematological and Immunological Parameters in Rabbits Treated with Parathion. Journal of High Institute of Public Health, 41(2), 268-281. doi: 10.21608/jhiph.2011.20157
Kawther El-Gendy; Nagat Aly. "Alteration of Hematological and Immunological Parameters in Rabbits Treated with Parathion". Journal of High Institute of Public Health, 41, 2, 2011, 268-281. doi: 10.21608/jhiph.2011.20157
El-Gendy, K., Aly, N. (2011). 'Alteration of Hematological and Immunological Parameters in Rabbits Treated with Parathion', Journal of High Institute of Public Health, 41(2), pp. 268-281. doi: 10.21608/jhiph.2011.20157
El-Gendy, K., Aly, N. Alteration of Hematological and Immunological Parameters in Rabbits Treated with Parathion. Journal of High Institute of Public Health, 2011; 41(2): 268-281. doi: 10.21608/jhiph.2011.20157
Alteration of Hematological and Immunological Parameters in Rabbits Treated with Parathion
1Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
2Pesticide Central Lab., Agriculture Research Center, Sabhia, Alexandria, Egypt.
Abstract
Background: Organophosphorus compounds (OP's) increase endogenous acetylcholine levels by inhibiting acetylcholinesterase. Their suppression of the immune responsesmight be due to direct actionofacetylcholine on the immune system. Objective: To investigate the effect of organophosphorus pesticide, parathion (0.2 mg/kg/day) for 14 consecutive days on the hematological parameters and the immune response of rabbits after different time intervals (1 hour, 24 hours, 1 week, 2 weeks and 4 weeks after the end of treatment). Methods: Blood samples were analyzed for hemoglobin content (Hb), packed cell volume (PCV), erythrocytes and leukocytes. The cellular immunity was assessed by lymphocyte proliferation response to mitogens; phytohemagglutinin (PHA) and lipopolysaccharide (LPS) and humoral immunity was measured by plaque-forming cell (PFC) generation and hemagglutination titer (HA). Also, nonspecific immunity was assayed by phagocytic activity. Results: They showed that parathion caused a significant increase of total leukocytes and monocytes, while blood erythrocytes, Hb and PCV were insignificantly reduced. Parathion caused a pronounced suppressive effect on the cellular immunity (lymphocyte proliferation response to PHA and LPS) and humoral immunity (PFC and HA). Also, a significant reduction in nonspecific immunity was observed. The suppressive effect of parathion on immune response was time dependent. Conclusion: The results of the present study suggested that the determinations of hematological and immunological parameters are useful tools for evaluating the toxic effects of parathion on animals.
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