Comparative Study on the Effects of Steviosides and Aspartame on Glucose, Urea and Creatinine Levels of Normal and Type 2 Diabetic Rats

Document Type : Original Article

Authors

1 Department of Nutrition, High Institute of Public Health, Alexandria University, Alexandria, Egypt

2 Department of Animal Physiology, Faculty of Specific Education, Alexandria University, Alexandria, Egypt

Abstract

Comparing the effects of the natural nonnutritive sweetener (steviosides) and the artificial sweetener (aspartame) on the plasma glucose, urea, and creatinine levels of normal and type 2 diabetic rats revealed that  treating normal and diabetic rats with different doses of both sweeteners reduced the plasma glucose levels except in normal rats treated with low dose of aspartame and high dose of steviosides that increased glucose levels by 17.3% and in normal rats treated with the high aspartame dose (3.8%) but fortunately they were still within the normal glucose range. All doses of both sweeteners increased urea levels in normal rats by percentages ranging from 5.2% to 41.7% though they were within the normal urea range except the low aspartame dose and high steviosides dose, moreover medium aspartame dose reduced urea level by 11.1%. All doses of both sweeteners reduced the urea levels in diabetic rats with the highest reduction percentage in those treated with the high steviosides dose (63.8%) while the lowest (40.9%) was in those treated with the medium dose of aspartame but unfortunately, no dose succeeded to lower urea levels to their normal ranges. Treating normal rats with different doses of both sweeteners increased the plasma creatinine by percentages ranging from 33.3% in the medium steviosides dose to 133.3% in the low aspartame dose although they were kept within the normal creatinine range. Treating diabetic rats with different doses of both sweeteners succeeded to lower creatinine levels to their normal ranges with reduction percentages ranging from 25.8% to 38.1%. The creatinine levels were more or less similar in diabetic rats treated with different doses of both sweeteners with no significant differences between the two sweeteners in any dose.

Keywords

Journal of High Institute of Public Health
Volume 38, Proceedings of the 2nd International Conference of the High Institute of Public Health "AlexHealth 2008"
Proceedings of the First International Conference of the High Institute of Public Health "AlexHealth 2008"
November 2008
Pages 102-112

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