Level of Basic Fibroblast Growth Factor in Breast Cancer Patients

Document Type : Original Article

Authors

1 Internal Medicine department, Faculty of Medicine, Alexandria University, Egypt

2 Clinical Oncology department, Faculty of Medicine, Alexandria University, Egypt

3 Clinical Pathology Department, Faculty of Medicine, Alexandria University, Egypt

Abstract

Serum basic fibroblast growth factor (bFGF) was determined before and after surgery in 40 female patients with cancer breast, 20 with no metastasis (group 1) & 20 had metastasis. Sixty percent of group I had elevated bFGF and showed a significant difference before and after surgery, while 80% of group II had elevated bFGF with no significant difference before and after surgery. The mean value of serum bFGF before surgery in group I was 7.64+2.96 and it was 4.91±1.89 after surgery compared 8.56±2.8 & 8.02±2.8 for group II. This indicate that bFGF has a direct relation to the tumor and its metastasis and surgery in non-metastatic tumor may normalized the level of bFGF and its increase may indicate metastasis.

Keywords

Journal of High Institute of Public Health
Volume 29, Issue 4
October 1999
Pages 725-730

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