Khamise, N., Tayel, D., Helmy, M., Aborhyem, S. (2020). Effect of Aspartame and Sucralose Artificial Sweeteners on Weight and Lipid Profile of Male Albino Rats. Journal of High Institute of Public Health, 50(2), 87-100. doi: 10.21608/jhiph.2020.108281
Nermin A. Khamise; Dalia I. Tayel; Maged W. Helmy; Samar Aborhyem. "Effect of Aspartame and Sucralose Artificial Sweeteners on Weight and Lipid Profile of Male Albino Rats". Journal of High Institute of Public Health, 50, 2, 2020, 87-100. doi: 10.21608/jhiph.2020.108281
Khamise, N., Tayel, D., Helmy, M., Aborhyem, S. (2020). 'Effect of Aspartame and Sucralose Artificial Sweeteners on Weight and Lipid Profile of Male Albino Rats', Journal of High Institute of Public Health, 50(2), pp. 87-100. doi: 10.21608/jhiph.2020.108281
Khamise, N., Tayel, D., Helmy, M., Aborhyem, S. Effect of Aspartame and Sucralose Artificial Sweeteners on Weight and Lipid Profile of Male Albino Rats. Journal of High Institute of Public Health, 2020; 50(2): 87-100. doi: 10.21608/jhiph.2020.108281
Effect of Aspartame and Sucralose Artificial Sweeteners on Weight and Lipid Profile of Male Albino Rats
1Faculty of Allied Medicine, Pharos University, Alexandria, Egypt
2Department of Nutrition, High Institute of Public Health, Alexandria University, Egypt
3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhur University, Egypt
4Food Analysis Unit, Department of Nutrition, High Institute of Public Health, Alexandria University, Egypt
Abstract
Background: Artificial sweeteners interfere with normal physiological processes. Objective: The study aims at assessing the changes associated with consuming different doses of aspartame (Sugar-Match®) and sucralose (Sweetal®). Methods: A total of sixty rats were divided into two phases; phase I was categorized into 6 groups including a control group, sucralose 2 and 4 g/kg, aspartame 0.8 and 1.6 g/kg, and sucrose with dose 0.5 mg/kg given orally every day for 12 weeks. Rats were euthanized and lipid profile was measured. Phase II comprised 4 groups including the same previously mentioned doses of sucralose and aspartame which were given orally every day for 12 weeks then omitted for further 6 weeks to study the ability of body to restore the biological changes associated with their consumption. Results: The highest triglyceride level was observed in rats fed on high dose sucralose (80.83 ± 5.46 mg/dl) and aspartame (78.83 ± 4.17 mg/dl). After 12 weeks of experimentation, cholesterol was higher in all groups. LDL-C was the highest in rats supplemented with a high dose of aspartame (43.90 ± 8.41 mg/dl), followed by a low dose of aspartame (39.28 ± 2.03 mg/dl). Terminating intake of artificial sweeteners caused large drop in LDL-C in rats fed on high dose of aspartame, while HDL-C increased slightly but insignificantly. Severe histopathological changes in liver and kidney tissues were observed in rats supplemented with a high dose of aspartame. Conclusion: Supplementing rats with aspartame and sucralose for 12 weeks increased lipid profile. Pathological changes were recovered neither in the liver nor in the kidney even after terminating artificial sweeteners intake.
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