Towards Physiological Function of Uric Acid: Studying its Relation to Disturbed Lipid Metabolism in Hypertension and Type 2 Diabetes

Qamar, Asser; Elewa, Samia; Wagdy, Eman; Abdel-Ghaffar, Abul-Soud; Toukhy, Mervat E.

doi:10.21608/jhiph.2006.161918

Towards Physiological Function of Uric Acid: Studying its Relation to Disturbed Lipid Metabolism in Hypertension and Type 2 Diabetes

Document Type : Original Article

Authors

¹ Physiology, Internal Medicine, Medical Research Institute, Alexandria University, Egypt

² Applied Medical Chemistry, Medical Research Institute, Alexandria University, Egypt

³ Departments, Medical Research Institute, Alexandria University, Egypt

10.21608/jhiph.2006.161918

Abstract

Background: Renewed interest in the possible role of uric acid in the pathogenesis of diabetes mellitus [DM] and hypertension had come into view in the last few years. Elevated serum uric acid [UA] concentration predicts subsequent development of diabetes mellitus and hypertension even in the presence of normal creatinine clearance and plasma glucose concentrations. Serum uric acid in conjunction with serum lipids are influencive factor in the development of hypertension with diabetes and without.
Objective: The study was performed to seek the relationship between serum uric acid level, essential hypertension, and type 2 diabetes mellitus and the influence of dyslipidaemia on the occurrence of these metabolic disorders.
Subjects and Methods: 110 subjects were classified into four groups, group A, the control group included twenty health subjects, group B included thirty diabetic patients, group C included thirty hypertensive patients, and group D included thirty diabetic hypertensive patients.
Results: The present study revealed a significant increase in serum uric acid, total cholesterol, low density lipoprotein cholesterol [LDL-c], triglyceride, creatinine, and blood urea levels in all studied groups as compared to the control group. Triglyceride and total cholesterol were significantly increased in diabetic hypertensive group as compared to the hypertensive group. High density lipoprotein cholesterol [HDL-C] levels were significantly decreased in all studied groups as compared to the control group and in the hypertensive group as compared to the diabetic group. A significant correlation has been found between blood sugar, blood pressure and all blood lipids in all studied groups. Moreover, the diabetic hypertensive patients showed clearly the primary insult.

Keywords