Ibrahim, H., Osfor, M., Abdalla, E., El-Kutry, M. (2005). Effect of Nigella Sativa on Heavy Metals-Induced Toxicity in Albino Rats. Journal of High Institute of Public Health, 35(2), 441-470. doi: 10.21608/jhiph.2005.179068
Hoda S. Ibrahim; Mostafa M. Osfor; Eveleen S. Abdalla; Mona S. El-Kutry. "Effect of Nigella Sativa on Heavy Metals-Induced Toxicity in Albino Rats". Journal of High Institute of Public Health, 35, 2, 2005, 441-470. doi: 10.21608/jhiph.2005.179068
Ibrahim, H., Osfor, M., Abdalla, E., El-Kutry, M. (2005). 'Effect of Nigella Sativa on Heavy Metals-Induced Toxicity in Albino Rats', Journal of High Institute of Public Health, 35(2), pp. 441-470. doi: 10.21608/jhiph.2005.179068
Ibrahim, H., Osfor, M., Abdalla, E., El-Kutry, M. Effect of Nigella Sativa on Heavy Metals-Induced Toxicity in Albino Rats. Journal of High Institute of Public Health, 2005; 35(2): 441-470. doi: 10.21608/jhiph.2005.179068
Effect of Nigella Sativa on Heavy Metals-Induced Toxicity in Albino Rats
1Nutrition & food Science Department, Faculty of Home Economics, Helwan University, Egypt
2Nutrition & Food Science Department, National Research Center, Egypt
3Home Economics Department, Faculty of Specific Education, Ain Shams University, Egypt
Abstract
This study was conduced to investigate the effect of adding Nigella sativa [NS] [5%] seeds on toxicity induced by both lead acetate and aluminum chloride at two levels {10% LD50 [L1] & 20% LD50 [L2]} which were fed to 60 adult male albino rats [118±5 g] for six weeks. Ten diet groups [6 rats each] 1- basal diet, 2- basal diet + NS, 3- basal diet + L1 Pb, 4- basal diet + L1 Pb + NS, 5- basal diet + L2 Pb, 6- basal diet + L2 Pb + NS, 7- basal diet + L1 Al, 8- basal diet + L1 Al + NS, 9- basal diet + L2 Al, and 10- basal diet + L2 Al + NS. Rats were fed as libitum during the experimental period at the end of the 6 weeks. Fasting blood samples were taken for biochemical analysis. Organs were removed & weighed then tissues were prepared for histopathological examination. All data were statistically analyzed. Results revealed that adding NS to the diet increased body weight gain [BWG] and food intake [FI] significantly in rats in all groups compared to the control. There were no significant differences in organ relative weight [liver, kidney, and brain] between groups fed either [Pb or Al] at any level with or without addition of NS. Adding NS to the diet contaminated with Pb & Al increased total protein & globulin and decreased cholesterol and triglyceride, serum creatinine, urea, GOT and GPT. Using NS in groups fed on [Pb&Al] increased Hb and RBC’s level significantly. Groups fed NS had reduced the blood level of Pb&Al compared to groups fed on Pb&Al alone. Liver and kidney tissue of rats fed L1 & L2 of Pb &Al plus NS showed nearly normal structure compared to the negative control. This study suggests that NS has a beneficial effect on heavy metals intoxication on HB and RBC’s.
View on SCiNiTO
Top