Shatat, H., El-Sahn, A. (2004). Effectiveness of Myrrh in the Treatment of Schistosoma Mansoni Infection: A Controlled Trial. Journal of High Institute of Public Health, 34(2), 425-436. doi: 10.21608/jhiph.2004.189741
Hanan Z. Shatat; Amel A. El-Sahn. "Effectiveness of Myrrh in the Treatment of Schistosoma Mansoni Infection: A Controlled Trial". Journal of High Institute of Public Health, 34, 2, 2004, 425-436. doi: 10.21608/jhiph.2004.189741
Shatat, H., El-Sahn, A. (2004). 'Effectiveness of Myrrh in the Treatment of Schistosoma Mansoni Infection: A Controlled Trial', Journal of High Institute of Public Health, 34(2), pp. 425-436. doi: 10.21608/jhiph.2004.189741
Shatat, H., El-Sahn, A. Effectiveness of Myrrh in the Treatment of Schistosoma Mansoni Infection: A Controlled Trial. Journal of High Institute of Public Health, 2004; 34(2): 425-436. doi: 10.21608/jhiph.2004.189741
Effectiveness of Myrrh in the Treatment of Schistosoma Mansoni Infection: A Controlled Trial
1Tropical Health Department, High Institute of Public Health, Alexandria University, Egypt
2Parasitology and Entomology, Tropical Health Department, High Institute of Public Health, Alexandria University, Egypt
Abstract
Chemotherapy is the main tool for control of schistosomiasis. Although praziquantel has high degree of efficacy and minimal side effects, yet concern was raised over possible low-level resistance. This necessitates search for new safe and effective drugs. The present study was implemented to evaluate the efficacy of Mirazid [oleo-resin extract of Myrrh obtained from the stem of Commiphora molmol]. 1184 recruits were parasitological screened using Kato-Katz technique and intensity of infection was classified into light, moderate, or heavy according to WHO Guidelines. Schistosoma mansoni infection was detected in 156 recruits [13.2%], they were equally allocated to one of three therapy groups either mirazid [600 mg] for 3 consecutive days, mirazid [600 mg] for 6 consecutive days, or single dose of praziquantel 40 mg/kgbw. Cure was monitored 3 and 6 weeks post-treatment by parasitological stool examination using quantitative Kato-Katz [4 slides/stool sample] and formol detergent techniques. Cure rate was [55.6%] for 3-days Mirazid, [45.8%] for 6-days Mirazid, and [94.3%] for praziquantel when assessed 6 weeks post-treatment. Results showed that cure rates decreased with increasing pre-treatment egg count for the 3 studied treatment groups. For the uncured subjects, the percent reduction in geometric mean egg count observed 6 weeks post-treatment was [-6%] for those who received 3-days Mirazid, [39.1%] for those who received 6-days Mirazid, and [97.2%] for those who received praziquantel. Based on the finding of this study, although Mirazid is a well-tolerated herbal drug with minimal side effects, yet if compared with praziquantel as an anti-schistosomal drug, it has a lower cure rate and is given in multiple doses with a compliance problem.
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