Saad, A., Abdel Mohsen, M., Kholeif, S., Mowafy, M., Mahdy, M., Mohamed, J. (2003). The Biochemical and Genotoxic Effects of Occupational Exposure to Vinyl Chloride Monomer. Journal of High Institute of Public Health, 33(1), 49-60. doi: 10.21608/jhiph.2003.199240
Aziza A. Saad; Mohamed A. Abdel Mohsen; Soha F. Kholeif; Mohamed N. Mowafy; Mostafa M. Mahdy; Jihan H. Mohamed. "The Biochemical and Genotoxic Effects of Occupational Exposure to Vinyl Chloride Monomer". Journal of High Institute of Public Health, 33, 1, 2003, 49-60. doi: 10.21608/jhiph.2003.199240
Saad, A., Abdel Mohsen, M., Kholeif, S., Mowafy, M., Mahdy, M., Mohamed, J. (2003). 'The Biochemical and Genotoxic Effects of Occupational Exposure to Vinyl Chloride Monomer', Journal of High Institute of Public Health, 33(1), pp. 49-60. doi: 10.21608/jhiph.2003.199240
Saad, A., Abdel Mohsen, M., Kholeif, S., Mowafy, M., Mahdy, M., Mohamed, J. The Biochemical and Genotoxic Effects of Occupational Exposure to Vinyl Chloride Monomer. Journal of High Institute of Public Health, 2003; 33(1): 49-60. doi: 10.21608/jhiph.2003.199240
The Biochemical and Genotoxic Effects of Occupational Exposure to Vinyl Chloride Monomer
1Applied Medical Chemistry Department, Medical Research Institute, University of Alexandria, Egypt
2Human Genetics Department, Medical Research Institute, University of Alexandria, Egypt
3Internal Medicine Department, Medical Research Institute, University of Alexandria, Egypt
4Management Manager of Development and Technical Studies, Egyptian Petrochemicals Company, Egypt
Abstract
Vinyl chloride [VC], is the starting point in the manufacture of the ubiquitous plastic poly vinyl chloride [PVC]. It has been classified by the International Agency for Research on Cancer [IARC] as group 1 carcinogen. The study was conducted with the aim of investigating the biochemical and genotoxic effects of occupational exposure to VCM. The study included 84 workers occupationally exposed to VCM; 54 working in the Petrochemical Company and 30 working in EI Masria company, and 20 subjects as a control. Biochemical assessment of the occupationally exposed group involved determination of glutathione [GSH] content in whole blood, erythrocyte glutathione peroxidase [GPx] and glutathione S-transferase [GST]. Twenty workers showed elevation in these biochemical parameters. They were subjected to cytogenetic investigations including blood cultures for sister chromatid exchange [SCE] evaluation and micronucleus [MN] assay. Cytogenetic evaluation was performed to 6 of the control group using both SCE evaluation and MN assay. Statistical analysis of variance between groups [One way ANOVA] revealed a significant decrease in GSH level as well as in GPx level in blood of workers when compared to the control group and a significant increase in level of GST in workers when compared to the control group.The mean SCE/cell for the exposed workers was higher than that of the control. The difference was statistically not significant [t=0.77]. The mean MN/500 cytokinesis blocked binucleated cells was higher in the occupationally exposed workers as compared the control group. The difference was statistically significant [t=5].
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