Abdelaziz, N., Fekry, M., Hashish, M. (2019). Occult Hepatitis B Virus Infection in Egyptian HIV-Infected Patients with Isolated Anti-HBc. Journal of High Institute of Public Health, 49(3), 162-167. doi: 10.21608/jhiph.2019.59201
Naglaa F. Abdelaziz; Marwa M. Fekry; Mona H. Hashish. "Occult Hepatitis B Virus Infection in Egyptian HIV-Infected Patients with Isolated Anti-HBc". Journal of High Institute of Public Health, 49, 3, 2019, 162-167. doi: 10.21608/jhiph.2019.59201
Abdelaziz, N., Fekry, M., Hashish, M. (2019). 'Occult Hepatitis B Virus Infection in Egyptian HIV-Infected Patients with Isolated Anti-HBc', Journal of High Institute of Public Health, 49(3), pp. 162-167. doi: 10.21608/jhiph.2019.59201
Abdelaziz, N., Fekry, M., Hashish, M. Occult Hepatitis B Virus Infection in Egyptian HIV-Infected Patients with Isolated Anti-HBc. Journal of High Institute of Public Health, 2019; 49(3): 162-167. doi: 10.21608/jhiph.2019.59201
Occult Hepatitis B Virus Infection in Egyptian HIV-Infected Patients with Isolated Anti-HBc
1Fellow of Microbiology Department, High Institute of Public Health, Alexandria University, Egypt
2Microbiology Department, High Institute of Public Health, Alexandria University, Egypt
Abstract
Background: Occult hepatitis B infection (OBI), defined as the presence of hepatitis B virus (HBV) DNA in liver or serum despite the absence of detectable hepatitis B surface antigen (HBsAg) is a frequent contaminant with human immunodeficiency virus (HIV). HIV has a negative effect on HBV disease accelerating its natural course. Objective: This study aimed to estimate the occurrence of OBI in Egyptian HIV-infected patients with isolated anti-HBc. Methods: This cross-sectional study was conducted on 197 HIV infected patients. They were tested for HBsAg, Antibody to hepatitis B surface antigen (anti-HBs), antibody to HBV core antigen (anti-HBc), and CD4 count. Patients with sole anti-HBc were screened for HBV DNA by polymerase chain reaction (PCR). Results: Among those patients, 13 (6.60%) were positive for HBsAg, 82 (41.62%) for anti-HBc and 70 (35.53%) for anti-HBs. Their corresponding median CD4 count was 310.00 cells/mm3, 497.50 cells/mm3 and 525.50 cells/mm3, respectively. Anti-HBc was the sole marker in 35 (17.77%) patients of whom 7 (20%) were HBV DNA positive indicating OBI. Most OBI patients were non-vaccinated against HBV. There was no significant statistical relationship between the presence of OBI and CD4 count, although most of them had CD4 count less than 500 cells/mm3. Conclusion: The present study underscores the importance of OBI screening among HIV patients with isolated anti-HBc.
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